Aminobenzoic acids and derivatives
![Aobchem 2-Methylbenzo[b]thiophene-5-carbaldehyde | 95% | CAS 56540-58-0 | C10H8OS | 5g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Aobchem 2-Methylbenzo[b]thiophene-5-carbaldehyde | 95% | CAS 56540-58-0 | C10H8OS | 5g
2-Methylbenzo[b]thiophene-5-carbaldehyde | 95% | CAS 56540-58-0 | C10H8OS | 5g
Aobchem 2-Chloro-4-hydroxy-5-methoxybenzoic acid | 97% | CAS 62936-24-7 | C8H7ClO4 | 1g
2-Chloro-4-hydroxy-5-methoxybenzoic acid | 97% | CAS 62936-24-7 | C8H7ClO4 | 1g
Aobchem 4-Bromo-5-chloro-2-methylbenzoyl chloride | 95% | CAS 2168177-56-6 | C8H5BrCl2O | 1g
4-Bromo-5-chloro-2-methylbenzoyl chloride | 95% | CAS 2168177-56-6 | C8H5BrCl2O | 1g
Aobchem N-Cyclopropyl-3 5-dimethylbenzenesulfonamide | 95% | CAS 1457571-32-2 | C11H15NO2S | 250mg
N-Cyclopropyl-3 5-dimethylbenzenesulfonamide | 95% | CAS 1457571-32-2 | C11H15NO2S | 250mg
Medchemexpress LLC α-CGRP (mouse, rat) | 83651-90-5 | 99.8% | 3806.25 | 1 MG
α-CGRP (mouse, rat) is a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, which acts as a potent vasodilator. It can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, and also relaxes colonic smooth muscle. This product has potential for use in cardiovascular, pro-inflammatory, migraine, and metabolic studies.
- Potent vasodilator
- Regulates innate lymphoid cell response
- Regulates insulin secretion
- Decreases mean arterial blood pressure
- Increases heart rate and systemic vascular conduction
- Plays a role in regulating Kainic acid-induced pyramidal cell death
- Reduces frequency and severity of epileptic seizures in mice
- Mitigates pathological damage in hippocampal regions
Sigma Aldrich Fine Chemicals Biosciences M344 >=98% (HPLC), powder | 251456-60-7 | MFCD03453554 | 1MG
M344 >=98% (HPLC), powder | Purity: >=98% (HPLC) | Mol Wt: 307.39 | 251456-60-7 | MFCD03453554 | 1MG
Medchemexpress LLC Alpha-Tocotrienol | 58864-81-6 | 98.8% | 1 ML
α-Tocotrienol is an isoform of vitamin E found in vegetables, fruits, seeds, nuts, grains, and oils. It acts as an antioxidant, helps in lowering cholesterol and other lipids, and functions as a neuroprotective and anticancer agent. It is also involved in cardiovascular disease protection.
- Functions as an antioxidant
- Helps lower cholesterol and other lipids
- Acts as a neuroprotective agent
- Acts as an anticancer agent
- Provides cardiovascular disease protection
Medchemexpress LLC Lenvatinib (mesylate) | 857890-39-2 | 99.7% | 522.96 | 25 MG
Lenvatinib mesylate is an oral, multi-targeted tyrosine kinase inhibitor. It inhibits vascular endothelial growth factor receptors (VEGFR1-3), fibroblast growth factor receptors (FGFR1-4), platelet-derived growth factor receptor (PDGFR), KIT, and RET. The compound demonstrates potent antitumor activities.
- Inhibits VEGFR2 with an IC50 of 4 nM
- Inhibits VEGFR3 with an IC50 of 5.2 nM
- Inhibits VEGFR1 with an IC50 of 22 nM
- Inhibits PDGFRα with an IC50 of 51 nM
- Inhibits PDGFRβ with an IC50 of 39 nM
- Inhibits FGFR1 with an IC50 of 46 nM
- Inhibits KIT with an IC50 of 100 nM
- Significantly inhibits local tumor growth and metastasis in preclinical models
Medchemexpress LLC Exatecan mesylate | 169869-90-3 | 101.1% | 531.55 | 50 MG
Exatecan mesylate (DX8951f) is a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.975 μg/mL). It is utilized in cancer research.
- Potent topoisomerase I inhibitor.
- Inhibits proliferation of several cancer cell lines (mean GI50s 0.877-2.92 ng/mL).
- Displays cytotoxic activities against PC-6 and PC-6/SN2-5 cells.
- Stabilizes DNA-TopoI complexes in PC-6 and PC-6/SN2-5 cells.
- Exhibits antitumor activities in mouse models without toxic death.
- Highly inhibits MIA-PaCa and BxPC-3 primary tumor growth in early-stage models.
- Suppresses BxPC-3 lymphatic metastasis and eliminates lung metastasis in late-stage cancer models.
Medchemexpress LLC Exatecan (mesylate) | 169869-90-3 | 101.1% | 531.55 | 1 ML
Exatecan mesylate (DX8951f) is a potent DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL). It is a light yellow to green yellow solid that can be used in cancer research. This product is provided as a 10 mM solution in DMSO, ready for laboratory applications.
- Inhibits DNA topoisomerase I activity
- Potent activity with an IC50 of 0.975 μg/mL
- Demonstrates significant inhibition of proliferation in various cancer cell lines, including breast, colon, stomach, and lung cancer
- Exhibits antitumor activity in in vivo mouse models
- Stable under recommended storage conditions: 4°C for sealed solid, or -80°C / -20°C for solutions
- Shipped at room temperature in continental US
Sigma Aldrich Fine Chemicals Biosciences Coenzyme A sodum salt hyd100MG
Coenzyme A (CoA) is an essential cofactor in living systems and is synthesized from pantothenic acid (vitamin B5) The CoA levels in mitochondria and peroxisomes correspond to 2-5 mM and 0.7 mM respectively. Cytosolic CoA is in the range of 0.05 mM to 0.14 mM
Medchemexpress LLC Tert-butyl (10-aminodecyl)carbamate | 216961-61-4 | MFCD02094501 | ≥97.0% | 272.43 g/mol | C15H32N2O2 | 25 G
tert-Butyl (10-aminodecyl)carbamate is a Boc-protected primary amine used as a synthetic building block and linker in medicinal chemistry and organic synthesis. It is supplied with documentation for safe handling and quality verification.
- Boc-protected primary amine suitable for linker and building-block synthesis.
- High purity for research applications.
- Provided as a 25 g pack for laboratory use.
- Documented safety and quality data available, including SDS and COA.
- Molecular weight 272.43 g/mol and formula C15H32N2O2.
Medchemexpress LLC A-484954 | 142557-61-7 | 99.6% | 289.29 | 10 MG
A-484954 is a highly selective eukaryotic elongation factor-2 kinase (eEF2K) inhibitor with an IC50 of 280 nM. It is intended for research use only.
- Highly selective eEF2K inhibitor
- Inhibits MDA-MB-231 cell viability at IC50 99480 nM
- Causes relaxation in E (+) and E (-) aorta or mesenteric artery
- Inhibits MCT-induced increases in PA pressure, PA hypertrophy, and fibrosis